MS Zuiderdam (pronounced /ˈzaɪdərdæm/) is a cruise ship owned and operated by Holland America Line. It is the first of the Vista classships, so named for the extensive use of glass in their superstructure. It is sister to the Oosterdam, Westerdam, and the Noordam. The names of the four ships translate to the four directions of the compass in Dutch.

The ship shares similar exterior dimensions with Carnival Cruise Lines' and Costa Cruises' Spirit Class. Cunard Line's Queen Victoria is an enlarged version of the same design, as is HAL's Signature Class.

As with all Vista-class ships, Zuiderdam is equipped with a diesel-electric power plant and an Azipod propulsion system, and eighty-five percent of her staterooms have ocean views and sixty-seven percent have verandahs. Her art collection carries a Venetian theme throughout the ship; the most dazzling features figures in the time of Carnival in Venice, created by Daniel Ogier.

The machinery spaces of Zuiderdam are vast and stretch along two of its lowest decks for the most part of the vessel.

MS Zuiderdam is powered by a CODAG propulsion system encompassing five (three 16-cylinder and two 12-cylinder) Sulzer ZAV40S diesel engines (built under license by Grandi Motori Trieste, now owned by Wärtsilä, in Trieste, Italy) and a GE LM2500 Gas Turbine.Zuiderdam was the first Holland America Line ship to use a CODAG propulsion arrangement, a GE LM2500 turbine or ABB Azipod propulsors. It is propelled by two 17.62MW, 160rpm synchronous freshwater-cooled ABB Azipod propulsors.